Maybe some here remember me complaining in one of my posts about leg pain from estrogen.  I never could figure out what was causing it and some, rightfully so, warned me of blood clots.  Well now I know what causes it.  The problem it turns out was simply dehydration.  My doctor told me that I wasn't getting near enough fluids and that with the tendency of estrgen  to coagulate the blood is causing slow circulation which leads to the pain in my leg.  He instructed me on how much fluid to drink in a 12 hour period and I have stuck to the regiment diligently and now the leg pain is gone.  He also said no caffeine.  I never realized that I was dehydrated because I was never thirsty.  But my leg pain goes away as long as I stay adequately hydrated which I got to tell you is work.  So maybe this will help someone else.  before you start taking estrogen be sure you keep hydrated.  Apparently it is very important while on HRT .

Yays for passing along safety information!

Hugs, Devlyn

This goes for Spiro too (I'm currently on Spiro but not E) - I have not been on it long, but I've had weird leg sensations (not quite pain, not quite comfortable) since the day I started taking it. Drinking more water helped. I was also not thirsty, by the way.

Quote from: Amy1988 on October 22, 2014, 07:16:30 PM
My doctor told me that I wasn't getting near enough fluids and that with the tendency of estrgen  to coagulate the blood is causing slow circulation which leads to the pain in my leg.

Estradiol has a tendency to increase vasodilation as well, in other words, dilate (widen) blood vessels which, if anything, improves blood circulation. Whatever the case, I'm happy that your leg pain is gone and that your doctor's recommendations worked like a charm. YAY!

Spiro is a diuretic so everyone on it absolutely needs to stay hydrated. If you're on progesterone that also has diuretic properties so it's very easy to get dejydrated and very sick on them.

As I found out the hard way last Friday.