I'm only on Spiro right now, and will be starting E when I've ramped up to the right dosage. I got my prescription electronically in the middle of a home exam, so I just took a detour to a pharmacy, and then took the pill while riding the subway from downtown to campus. At that time, I had waited so long for this, that it no longer really felt like a big thing, if that makes any sense - there was nothing to consider, I knew I needed it, and it was just good to finally get something to get this poison out of my body. It felt as matter-of-course as taking my daily vitamins.