The estrogen bit is a good point.
@Tysilio
For some reason I've only ever maintained or lost weight after drinking, probably due to my strong dislike for beer.
@Jayne
After my friend moved out and his dad broke in I was drunk for a week. I file a police report, aced a job interview, and worked twice within that week. Needless to say I'm definitely at risk of alcoholism.
That being said, I am well aware of the effects of both depression and recreational substances on my rewards system, so I often try to remind myself of that.