Hmm.
Sarah Kerrigan, especially her new form in Heart of the Swarm.
Samus Aran.
EDI, Thane Krios, Eve, the Rachni Queen and for some reason, Legion, from Mass Effect.
Some female and gender-ambiguous characters from Fallen London and Sunless Sea, and also the Rubbery Men. Those poor squiddies are surprisingly much like us, when you think about it. Aside from, you know, being alien amber-traders who have tentacles in their faces.
Kate Marsh from Life Is Strange.
...That's everyone I can think of at the moment. I'll add more if I remember somebody else.