Do you swallow estrogen pills? If so, it might be helpful to consider taking your E another way. Oral E yields high E1 levels because the liver converts most of the E2 to E1 before it is absorbed into the bloodstream. Since E2 is the best feminizing agent, that conversion is not helpful. My E1 was much higher when I took my hormone orally than on any other routine. I have since stopped oral estradiol for another reason (candidiasis and yeast infections).