Yes, this has happened to me. I address the issue by donating blood every 3-4 months. Since I have been a somewhat regular donor for many years, it is not such a big deal for me. I do NOT like that fact that T has changed my blood chemistry, since I am already predisposed to genetic circulatory problems that make me worry about stroke and heart blockage, but I feel it is my best option right now. I am nearly 5 years on T, and the RBC/hemoglobin started creeping up after about 3 years.