Hi Megan,
Yes, there are a few active groups and, of course, Portland has the most going on. There is the Q Center, NW Gender Alliance and Basic Rights Oregon in Portland which is also home to the infamous TGirls social club. Salem has a Salem Transgender Network, Astoria has a new Lower Columbia Q Center and Gender Alliance, There are PFLAG groups all over and the Universities have local LGBTQ groups. Transgender Oregon Network is on Facebook as are a number of special interest and by invitation meet up sites. We had the first openly transgender elected Mayor, Stu Rasmussen. I like being part of the LGBTQ world here and hang out with several groups including the Rosetown Ramblers, a square dancing club. Lots happening if you look for it. Those PDX groups also maintain lists of medical and mental health providers. Some trans people get counseling by Skpe when they are very rural.
I am often at the coast near Astoria or in Portlandia helping to keep it weird

I love the NW and you know this rainforest has some fresh storms blowing in right now. PM me for more.