Quote from: Deborah on March 05, 2016, 10:05:39 PM
They haven't been testing for that on my previous visits. When I go to the endo this week I am going to ask about increasing the dosage now that I have gotten my blood pressure consistently in the normal range, below 120/80.
Progesterone is not a contraindication in individuals with high blood pressure. It can even prove to be beneficial. It exerts an antimineralocorticoid action, similar to spironolactone.
Climacteric. 2012 Apr;15 Suppl 1:11-7"Micronized progesterone has a neutral effect on the vasculature, including
a neutral or beneficial effect on blood pressure"
Climacteric. 2011 Feb;14(1):92-9."When micronized progesterone was added to the CEE treatment, the increase in daytime blood pressure in the group with normal blood pressure was abolished, and the decrease in systolic blood pressure throughout the day in the group with high blood pressure was potentiated. "
"Micronized progesterone may provide beneficial effects on blood pressure when combined with CEE."
Biol Psychol. 2005 Apr;69(1):39-56."Results showed that women assigned to Estratab plus Prometrium and Estratest had diminished systolic blood pressure responses to stress upon retesting, whereas the other groups did not change in the level of their responses. Women assigned to Estratab plus Prometrium had diminished diastolic blood pressure responses during a speech stressor upon retesting"
Climacteric, 8 (Suppl. 1) (2005), pp. 3–63"Oral treatment (...) led to a dose-dependent decrease in blood pressure221"
Clin Ther. 1999 Jan;21(1):41-60; discussion 1-2."The results of published clinical studies show minimal or no changes in lipid profile, blood pressure, or carbohydrate metabolism during treatment with oral micronized progesterone.28"
Lipids Health Dis. 2012 Oct 9;11:133."Blood pressure, glucose, insulin, HDL-c, triglycerides, and usCRP remained constant with or without micronized progesterone."
PLoS One. 2014 Jan 21;9(1)"Results indicate that progesterone has short-term cardiovascular safety. Endothelial function, weight, bloodpressure, waist circumference, inflammation and coagulation were unchanged as were lipids except for HDL-C. The statistically significant decrease in HDL-C levels was not clinically important"
J Hypertens. 2003 Jun;21(6):1145-9."We conclude that progesterone given without oestrogen does not adversely affect vascular function in postmenopausal women."
Climacteric. 2013 Aug;16 Suppl 1:44-53."Natural, 'body-identical' progesterone, devoid of any androgenic as well as glucocorticoid activities but
being slightly hypotensive due to its antimineralocorticoid activity, appears to be the optimal progestogen in terms of cardiovascular effects, blood pressure, VTE, probably stroke and even breast cancer"
Natural Progesterone: What Role in Women's Health Care?
Whether it's right for your patient depends on the specific setting
JANE L. MURRAY, MD"Micronized progesterone appears to achieve this effect without producing any adverse effects on hemostasis, blood pressure, or levels of other lipids, probably because it has virtually no androgenic side effects."
Endocrine Reviews, April 2013, 34(2):171–208"Interestingly, no changes were observed in blood pressure with progesterone administration
to normotensive postmenopausal women, although
a slight reduction in blood pressure was observed in hypertensive women (198)."
