What does it then mean when I see that during the peaks of the cycle (when I am taking the most amounts of estradiol), my hands roughen up? I'm checking to see in subsequent cycles (if my doctor will allow me to continue on this) whether this is a repeatable pattern. I noticed that when coming off the secondary peak into the end of my cycle (when I am at the base dosage), my hands would soften back up a bit. I guess I need more time, as cycling is very recent for me (ending second cycle, in fact).