Hi gang. Hope you're all well. I've been on HRT 18 months now, with no issues and pretty good feminisation. I haven't had any bloods done for around a year over and above the normal LFTs etc my endocrinologist orders so just out of interest got my T, E and Prolactin levels checked and results are messed up.

I take the following:

1. Zoladex/Goserelin (GnRH agonist) implant every 12 weeks
2. oral micronised Progesterone for the first 12 days of every month
3. IM Estrogen every 3.5days

I also have Pregnenolone and Finasteride but generally don't take them.

My bloods were taken at 10am the day AFTER an injection.

Prolactin was 541.1 mIU/L
Testosterone was 21.29 nmol/L
17-Beta Estradiol was >11010 pmol/L

E seems MEGA high?

What's everyone's thoughts? Apart from hot flushes I have no sides, good boobage development etc but it was an interesting result...

Xx

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Welcome to Susan's Place. You are correct about the level being high. Yes, it's possible to hit that number in pregnant women but it's not a normal dosage. One complication is you are taking the level just after injection and normally it's taken before an injection or an adjustment factor needs to be used. Your estradiol levels will drop reasonably fast so you might be as low a a quarter your current level before the next injection however without an end measurement, it's hard to tell. The solution is a lower dose or longer periods between injections but discuss this with your doctor. A week injection is pretty common among those on the site so that may be part of the solution.

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Quote from: thisisbecky on March 30, 2017, 08:55:29 PM

My bloods were taken at 10am the day AFTER an injection.

If your blood levels were taken AFTER your injections, they are on the high side of the peaks and valleys of blood levels. This will give you an artificial higher than normal reading. Blood levels should be drawn right before your next dose to get a good reading on the valley, your lowest blood level. Most clinicians feel that a mid cycle blood level is not that valuable in determining a proper dose.

Next time you are getting a blood level, hold off taking your injection until after the blood is drawn.

I've been on IM EV for 3 yrs now and injecting every 5 days. My levels measured on day 3 were around 8,500-9,500 pmol/L and once they were at + 14,000 pmol/L, typical of first trimester pregnancy levels. So, no surprise there and I'm thinking you're probably injecting a lower dose than me. Everything else came back normal and as expected given my high E2 levels. So, my doctors saw no reason to change anything.

My testosterone, in contrast to yours, was much lower, around 0.3-0.1 nmol/L. I find it VERY strange that your levels are so high (well within male range) unless these were measured soon after your implant which can bring up levels but if taken chronically, eventually T levels should drop to castrate levels and stay there.

Also, my prolactin levels were much higher. I'm taking oral micronized P every day instead of the first 12 days.

Hot flushes, by the way, is an indication of too low estrogen or testosterone so also seems odd unless this occurs when you stop progesterone or at certain times, when T drops again. You should discuss these matters with your doctor.

Finally, why 3.5 days? What made you and your doctor decide this was the optimal interval for you?