Yes, I have noticed major effects on my face. They are all fairly subtle: you can't necessarily tell what the difference is. But the combined effect is amazing. My face no longer looks male. I don't look totally female either, but on the femme side of androgynous. The biggest changes have been my lips, which are so different that I initially didn't recognize them, and around my eyes.
When I look in the mirror, I see a woman looking back.
In my avatar pic, which I have also posted, in a larger version in the Fabulous and Before and After threads, I am wearing very little makeup. Just a bit of foundation to cover irritation from electrolysis, and some lipstick.