Hmm, interesting question..
Androgen Deprivation Therapy is a protocol used in prostate cancer patients. It's essentially a sufficient dose of E to shut down T production, similar in aim to HRT. Now, one would expect there to be a lot of dysphoria on those being treated, however, it doesn't seem to be the case. Take from that what you will.
With that said, I've also had far less issues with all facets of mental health since changing to an E only protocol.