Quote from: TonyaW on November 03, 2018, 07:32:37 AM
The DVT risk with estradiol is only theoretical. Premarin and synthetic types used in oral contraceptives have shown a risk so it a precaution that really hasn't been proved or disproved.
Actually, studies on usage have shown that oral admin of estradiol does have an increased clot risk over other delivery methods. Nothing theoretical about it. And that's also far from reason given by most doctors - who will tell you all estradiol causes stroke/DVT.
QuoteThe drug is already on the market and available generically, so no drug company is going to lay out the cash for clinical trials regarding dosing and side effects, especially for a relatively small patient population. With out the cash from drug company marketing, you are very correct in that it's going to take a while for any improvements to become standard treatments.
Where did I ask for a clinical trial? Where did I even suggest a trial? Oh, I didn't. A specific clinical trial is not only way to obtain the needed data. And, funnily enough, there's a fairly recent clinical trial on estradiol administration for a non-trans related condition that is just full of useful data. It also includes a comparison to a selection of antiandrogens with the aim being complete gonadal shutdown.
Use an old drug in a "new" way, you'll need a clinical trial before you can claim it's best practice.. The only real delay at this point is the glacial pace at which trans medicine seems to educate itself. I know of a member here who is/was a medical professional. they still believe all sorts of old and odd things about estradiol that are not even based in fact.
