New insights into SRY regulation through identification of 5' conserved sequences

http://7thspace.com/headlines/295176/new_insights_into_sry_regulation_through_identification_of_5_conserved_sequences.html
10/14/2008

SRY is the pivotal gene initiating male sex determination in most mammals, but how its expression is regulated is still not understood. In this study we derived novel SRY 5' flanking genomic sequence data from bovine and caprine genomic BAC clones.

What does that mean?

Very roughly, the SRY gene (a small segment of the Y chromosome) is the 'master switch' regarding sex. This study has identified a few other gene sequences that have something to do with determining what happens when that master switch is flipped from 'female' to 'male'. They also suggest that mutations in these might have something to do with intersex conditions where a woman has a Y chromosome.

  Nfr

thank you for the crayon edition. Now I understand it.