I just thought I'd post this here for anyone who's interested. This is one of the most transgender inclusive games I've ever played.
It's an RPG primarily, however you can do pretty much whatever you want within it... including cross dressing, having gay relationships (yes, even the 'S' word) and gay marriages, buy and run real estate... there's even a side quest that offers a sex change potion as a reward (and a fun little sub-quest that allows you to be really evil and gives you a chance to change the genders of innocent people you coerce into following you into a place called the Temple of Shadows... they call it sacrificing but hey...)
You create your own character and then the world is largely your oyster. You can be good or evil, pure or corrupt (and yes, chances are you
will contract an STD from having unprotected sex with the... practitioners of the world's oldest profession).
And the game has some excellent speech from the likes of Zoe Wannamaker, Stephen Fry and Julia Sawalha. Not to mention that the gameplay, sound and graphics are stunning.
For anyone with an Xbox 360... very, very highly recommended.