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Depression and E

Started by JungianZoe, May 02, 2011, 12:27:40 AM

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JungianZoe

Did any of you notice a marked change in depression/happiness after you started HRT?  I usually have seasonal depression (pretty bad) but this year it's simply not going away.  The only real change from this year to last is that I'm now on HRT and full time.  I've had moments where I feel this is the time of my life, and too many, like tonight, where everything sets me off, and the pain burns more brightly than I've ever felt before.

Maybe it's also because I have the flu, but this weekend truly sucked and I never got out of my apartment due to illness.  So all this time alone, friends busy and not answering calls, no responses to texts, and now my thoughts are in doom and gloom mode.

"I didn't get into grad school and everyone I know who applied did."  Oh, so I'm a total failure.
"I haven't had a date in three years."  Now I'm ugly and unapproachable too.
"Why doesn't anyone pick up the phone?"  Because I'm being clingy and needy and I should stop.
"I'm depressed."  Nobody wants to hear it, it's only me, and who cares anyway?
"Really?  Your happiness doesn't matter?"  Got that right.

Now my job ends this week, I don't have another one lined up, and I find myself too depressed to even move.  I'm not normally this way.  I'm usually the one who brings sunshine to everyone else and cries alone where nobody can see.  I think it's to a point where everyone expects me to be sunshine, and I can't do it.  If I can't bring joy to others, what's the point in reaching out?

This is just so typical of my thoughts lately, and they should be gone by this time of year.  I'm trying hard to be confident, but it's difficult when I feel like I'm the ugly duckling who'll never pass in a million years.

Did anyone else have this type of depression when starting E?  Did it go away?
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CrazyTina

It didn't go away at all... But my situation and my life seemed as if it couldn't get any worse. When I awoke spiritually my depression lifted! I am now able to cut through the illusion of suffering, and transcend my doom and gloom outlook, as you call it, also known as the Pain Body, which is a Manifestation of the Ego.

Meditation was what ultimately ended up curing my Depression... and when it tries to come back and plague my thoughts, I know that it is not the truth.
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Caith

I've had clinical depression for years and it greatly lessened the first six months I was on a very low dose of estrogen and spiro.  I've always tended to feel seasonal effects as well.  In my case, taking E didn't make any difference at all.  I really hope it's just the flu dragging you down and has nothing to do with your HRT.
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Jinny

I went through a period of depression a couple of years back when my brother died - it knocked me sideways as I have always been a really upbeat person! I worked my way through it with mediation - I now continue to meditate on a daily basis & it's amazing how it has enhanced my life!
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MarinaM

My depression / anxiety worsened on Spiro alone, and then improved within 24 hours of taking E. I still have the thoughts, but they don't bother me, and I'm able to go and think about something else after a few moments.
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Ann Onymous

Do not recall any depressive episodes, although admittedly, that was a LONG time ago.  What I DO recall was becoming weepy at certain scenes in movies that never created an issue before, so there was definitely some measure of a change to the emotional balance...
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Arch

#6
Mind if I intrude? For a couple of decades, I felt that female hormones were causing or at least contributing greatly to my depression. I did not consciously think of it as a trans thing--I wasn't thinking, "If only I could get the right stuff in my brain." (Yes, I was terrifically compartmentalized and did not want to think about how my being trans was contributing.)

I always had a big mood swing around the time of the Red Death. Down, down, down. And I was depressed already.

I now think that the issue is more complicated, but I do think that the female hormones messed me up. Could be because my brain was over-testosteronized when I was developing (so it was running on the wrong juice, or something), or could be because female hormones are tricky. Maybe both.

I had a GYN who scoffed at my theory that I had a hormonal imbalance, so I never brought it up to any doctor again. Then I started noticing studies that showed links between depression and female hormones. I think that usually it was an issue with the proportion of E to P or something. Maybe yours needs tweaking?
"The hammer is my penis." --Captain Hammer

"When all you have is a hammer . . ." --Anonymous carpenter
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rejennyrated

Arch nailed it... and that is the reason why I think doctors like Richard Curtis in the UK who won't prescribe Progesterone are complete idiots! I take a small dose of Progesterone because without it I get into a depressive spiral and my libido collapses. It is a tiny dose - but if makes a huge difference to my equilibrium and well being.

So I agree - get the balance tweaked. (Oh and make sure you get a proper micronised progesterone and not that medoxy synthetic rubbish!)
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Rock_chick

I upped my E dosage recently and I've felt a hell of a lot better, i'm also on progesterone as well.
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JungianZoe

Thank you, each and every one, for responding with the little tips and hints!  I found out today that one of the side effects of depo is depression, and that could be (in part) what I'm experiencing.  When I was on spiro and E, I didn't feel this way (my T levels stayed at 650 though, so no suppression).  In fact, on spiro, I cranked out my honors thesis, worked 30 hours a week, took another class, and went through the entire grad school application process.

Now my productivity is shot.  T levels are nicely suppressed, but switching to depo caused what I know to have been a bit of depression for the first three months of the year.  Then, in March, my doc doubled my E on top of the regular depo shot.  Things have been sliding downhill ever since, to the point that I even told a friend last night that I was a monster who crushed everything she loves.

Today's been a bit brighter since I was able to get out of the house (therapist appointment and work) but now that I'm home, that old feeling is coming back.  I have a long history of suicidal depression going back to my first attempt at the age of 11, and while I can say this isn't as bad as my darkest moments, those darker moments are full of nasty thoughts instead of being total voids like they once were.  I try so hard to tell myself good thoughts, but the stupid crap my abusive stepmom fed to me rises to the surface.  But I try... I really do try to break that pattern and put better thoughts in their place.  My friend also told me last night that it sounded like the boy self was pushing through, not the shining girl that she's come to know the past few months.

I consider myself very spiritual, but not religious.  No matter how much I've read about mindfulness, all of that teaching goes out the window when I'm at my worst (at the time I need it the most).  The dark thoughts are so stubborn that they push away good thoughts.  The more positive the thought, the harder it pushes.  Maybe it's just practice, I don't know.  But I'm just tired of spending the last two or three hours of every day in tears, unable to move a muscle because my whole body feels like it's carrying a jetliner.

As far as reaching out goes, I'm just not good at it.  My dad and stepmom abused me physically, mentally, and emotionally, but my mom and stepdad had a strict "no whining" rule.  You didn't talk unless it was cheery and they didn't want to hear anything else.  Though they support me in my transition, they still tune out as soon as you say something is wrong (and sometimes begin to yell that they don't want to hear about my problems).  They'll share in joy, but nothing else.  So I very much have a fear of reaching out to anyone at all.  If my parents won't even listen, then who will?  I don't want my friends to disappear because I'm not smiling.

Ugh... I'm just going to shut up now.
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BunnyBee

Sorry in advance for the ADDishness of this post but I forgot to take my medicine this afternoon, so...

I'm not saying that your friends shouldn't listen to you when you're sad or upset, because friends should do that, but I want to say I had an epiphany a while ago that the role of a therapist was to listen to you bitch so the people you love didn't have to.  Before that I never even understood the point of going to one, maybe I still don't, but the idea of paying somebody $100 so I can just whine at them for an hour has been sounding kind of awesome lately.  Maybe that is an option?  Do that more?  Could be expensive after a while.

I am like you in that I don't like dragging my friends down with me when I feel bad, but talking about your issues is sometimes the best cure for them.  Especially on estrogen, the need to connect with other people is just overpowering, at least for me.  Neglecting that is a bad thing, I'm thinking.

Also, I think it's telling that going out of the house made you feel better.  Maybe you should try to do that more?  Staying inside all by yourself is a recipe for depression.

Anyway I am trying to say, make connections with people and get your upsetness off your chest.  Those two things.  If you don't have a therapist or anybody else to turn to, lmk and I'll give you my info :).
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Jacelyn

Estrogen alone can cause depression, that's why the need for androgen or progesterone to balance the estrogen dominance effect, also may try Vitamin E 400 IU supplement, it has progesterone effect,  it may mitigate some of the estrogen effect (in a positive way).
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JungianZoe

Jen, I do have a therapist, but sadly lack the funds to go more than once every month or so (thankfully she's totally cool with the scheduling being on my terms as far as transition goes, not insisting on any set timeline).  As soon as I find a job, that's going to increase because I feel I do need it more often.  I felt pretty strongly last week that I was foisting too much of this negativity onto my friends, it was getting out of control, and so I made the appointment that I had this morning.  Probably needed two hours to get it all out because the one barely sufficed.  :laugh:

What you say about estrogen and connections is so true, and I never realized it until my T levels were under control and E finally got a chance to work.  My mom told me I was a hermit for the last 10 years before coming out and it was an incredibly accurate description... I probably hung out with friends less than 20 times in 10 years.  I'd sometimes go four or five months without even talking to anyone on the phone and never realized it.  I had to get pretty damn lonely to pick up the phone and make a call.  Often, I ignored calls, texts, and emails because I so completely shut out the entire world.

But since starting HRT, there isn't a day goes by that I don't want to talk to each and every one of my friends.  I went from sending about 20 texts a year to about 2500 in one month.  My parents helped me save a bit of money by putting me on their cell phone plan (along with the rest of my siblings) and I beat my stepdad's long-standing record for minutes used.  Thankfully, we were still nowhere near the monthly maximum!

Also, you're absolutely right about getting out of the house.  I never want to be indoors anymore.  For the first time in a decade, I've actually seen spring, smelled flowers (like literally, stopping in my tracks to smell them), got back into photography, and checked off a couple of bucket list items.  Maybe some of my being upset this past weekend was being trapped indoors with the flu.  But despite all of my wonderful experiences lately, the moments that I'm alone, in my apartment, aren't good times.  I think I need to learn how to cool down the social butterfly that's awoken inside of me.  My therapist asked me today if I considered myself an extrovert, to which I realized that I might be all of a sudden.  I always proclaimed a fierce introversion, but that appears to have done a 180.  I used to get worn out by a 10-minute phone call, now I think I could wear out an entire European hamlet in 10 days and have enough social energy left over to conquer Orlando.  Or maybe Topeka... who knows. ;D


EDIT: Is depo a form of progesterone, or no?  I've seen conflicting info on that one.
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FairyGirl

Estrogen has the opposite effect on me, but I don't know what is this depo you speak of.  Once I was on progesterone for a while however I got over the roller coaster mood swings, but when I had to be off it for about 2 weeks I was totally overcome by what I can only describe as a horrible sense of weltschmerz...

from Wikipedia:
The modern meaning of Weltschmerz in the German language is the psychological pain caused by sadness that can occur when realizing that someone's own weaknesses are caused by the inappropriateness and cruelty of the world and (physical and social) circumstances.  Weltschmerz in this meaning can cause depression, resignation and escapism...

It was a kind of world weary sadness that things could never possibly be right.  It bordered frighteningly near dysphoria, which I hadn't felt since my SRS surgery.  As soon as my progesterone levels were restored (and my estrogen dose tripled) I felt happy, cured, and in control again.  Hormones can definitely have a big effect on our moods, so I wouldn't rule out something to do with that as the cause.

Jen's suggestion of getting out and having more interactions with others is also good advice.
Girls rule, boys drool.
If I keep a green bough in my heart, then the singing bird will come.
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andream

Quote from: JungianZoe on May 02, 2011, 06:25:15 PM
Thank you, each and every one, for responding with the little tips and hints!  I found out today that one of the side effects of depo is depression, and that could be (in part) what I'm experiencing.  When I was on spiro and E, I didn't feel this way (my T levels stayed at 650 though, so no suppression).  In fact, on spiro, I cranked out my honors thesis, worked 30 hours a week, took another class, and went through the entire grad school application process.

Now my productivity is shot.  T levels are nicely suppressed, but switching to depo caused what I know to have been a bit of depression for the first three months of the year.  Then, in March, my doc doubled my E on top of the regular depo shot.  Things have been sliding downhill ever since, to the point that I even told a friend last night that I was a monster who crushed everything she loves.

Today's been a bit brighter since I was able to get out of the house (therapist appointment and work) but now that I'm home, that old feeling is coming back.  I have a long history of suicidal depression going back to my first attempt at the age of 11, and while I can say this isn't as bad as my darkest moments, those darker moments are full of nasty thoughts instead of being total voids like they once were.  I try so hard to tell myself good thoughts, but the stupid crap my abusive stepmom fed to me rises to the surface.  But I try... I really do try to break that pattern and put better thoughts in their place.  My friend also told me last night that it sounded like the boy self was pushing through, not the shining girl that she's come to know the past few months.

I consider myself very spiritual, but not religious.  No matter how much I've read about mindfulness, all of that teaching goes out the window when I'm at my worst (at the time I need it the most).  The dark thoughts are so stubborn that they push away good thoughts.  The more positive the thought, the harder it pushes.  Maybe it's just practice, I don't know.  But I'm just tired of spending the last two or three hours of every day in tears, unable to move a muscle because my whole body feels like it's carrying a jetliner.

As far as reaching out goes, I'm just not good at it.  My dad and stepmom abused me physically, mentally, and emotionally, but my mom and stepdad had a strict "no whining" rule.  You didn't talk unless it was cheery and they didn't want to hear anything else.  Though they support me in my transition, they still tune out as soon as you say something is wrong (and sometimes begin to yell that they don't want to hear about my problems).  They'll share in joy, but nothing else.  So I very much have a fear of reaching out to anyone at all.  If my parents won't even listen, then who will?  I don't want my friends to disappear because I'm not smiling.




I agree with rejennyrated that progesterone helps to improve mood and libidio - I find the same thing. The past 3 days I haven't taken my progesterone because I have run out, and I have sort of fallen into that old pattern of hopeless thinking. I also was suicidally depressed in my teens, since thirteen, and I had many attempts, although non were successful (well obviously, since I am here writing this :P).

I'm also like you in that I feel I am responsible for destroying or damaging many of my loving relationships in the past. I often feel like I am bad person for pursuing transition to the detriment of my wife, my family etc. My stepmother told me "you need to consider others when you take action" implying that I didn't consider the impact on my loved ones when I started all of this. In the same conversation she told me "I prayed to God to have a daughter when I had your younger sister, because I already had a son. I don't believe God can be wrong". Well, what a wonderful thing for her to say, which is really a circuitous way of expressing that she doesn't believe I am female. Thanks mum. I simply replied "I don't believe in your religion, I can only follow my heart.". She was silent for a moment, and told me that she understood, although she didn't agree.

Unlike you, my parents were never abusive - they always took wonderful care of me, and showed me love in their own way. We were always rather distant physically (never any hugging or kissing) and my father was never able to connect emotionally. However, when I was in the throes of teenage depression, cutting my wrists, putting my head in the oven with the gas on, things like that, dad always made it about him. "Why are you doing this to me?" was a common thing he would say. Finally one day, when I was 16 or 17, he said to me "Poor you, you always expect people to help you." I have never forgotten that, even though 15 years later dad is different now, and far more open. I always knew it was a chemical thing, and combined with general teenage angst, and feeling like a freak for wanting to become a girl didn't help. Finally I went on Prozac and after a year I got better.

That was a bit of a tangent I guess. With regards to depression and hrt, my first six months of hrt I was in the best mood of my life. Then I started Androcur and injectable estradiol valerate, and that sent me into the worst depression I have ever experienced. I spent six months unable to find any joy in anything, and all I could think of was finding a way out of the pain, in other words dying. I began to research euthansia methods, and found a method that I could use that was simple, painless, with easily obtainable materials. I bought all the implements and left them sitting in my cupboard for weeks. Then when the day came for me to do it, I set everything up and just sat in my room sobbing for hours. See, I could never do it. I knew I could never do it, because I knew I didn't want to die, I just wanted the pain to go away. In my mind, when I would picture the act of dying, I could never mentally follow through. If I could never mentally follow through, I knew I could never physically follow through. I threw all of the suicide stuff away after that.

For me, Androcur was a huge contributing factor in the depression. Once I stopped taking it my mood lifted, although I do get down on occassion, and still think of suicide as an option, but I am more in control of my emotions now, and whenever those thoughts surface I understand that it is partly hormonal, and partly my frame of reference which I have built over many years. I read a post on susans recently where somebody wrote something like "Once you have considered suicide, it will always remain an option in your mind". For me that rings true. I am convinced that clinical depression is predominantly chemical, but the way you deal with it, that's self-disicipline and habit. If, when you are depressed, it is your habit to stay at home with the lights out, brooding and listening to sad music, and contemplating suicide, that is something you can change. It's all about forcing yourself to go out and do things that make you happy. I think things like exercise, clean diet, not drinking or taking drugs, and having good friends around you helps. Ultimately, it's about thinking about other things that help. When depressive feelings surface I like to do things like focus on work, go out and have a nice meal, or play a challenging video game.

If your friends are real, then they will stay by your side regardless if you are smiling or crying. They know the true beauty inside you. They will understand that you are going through a difficult time in your life. If they disappear, then, my dear, we call those "fair weather friends" and those aren't worth having. I might be overstepping a boundary here, but I would say the same for parents. If they want nothing to do with you when you are unhappy - when it REALLY counts - what in heavens are they good for?

However, while we can leave friends who don't treat us in the right way (god knows I've cut off all ties with putative friends who have used me one too many times) we are usually stuck with our parents. Sometimes, with parents, you need to force things. You need to come out and tell them that you need them to listen to you, good and bad, and if you have an argument, that might be viewed as a good thing. A good argument, where you express your real emotions, will bring truth out into the open, and if your relationship with your parents is meant to be, then it may draw you closer. It could go the other way though.

I guess I'm just saying if you want your parents to understand and listen to you, you need to keep going to them time and again and express your emotions, make it clear how important it is that they listen to you, and if they don't listen the first time, then try again, and again until they relent. You're their child, you have a right to badger them about your feelings, just as they have a right to tell you how they feel, be it negative or positive. You may very well end up arguing. You may well end up arguing a LOT. I personally think every argument in which true feelings are expressed is productive, as long as the dialogue continues afterwards and nobody says "I'm never talking to you again, get out of my life". I don't know, it might work, it might not, that's how I do it and it works with my parents, but my parents chalk that down to stubborn and flakey me.

Quote from: JungianZoe on May 02, 2011, 06:25:15 PM
Ugh... I'm just going to shut up now.

There's no need to tell yourself to shut up, we're all here to listen to one another and support one another through what, for many of us, is an extremely difficult path. You should never have to apologize for feeling the way you feel.
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andream

Quote from: JungianZoe on May 02, 2011, 07:24:36 PM
EDIT: Is depo a form of progesterone, or no?  I've seen conflicting info on that one.

You'd better check! If it's depo provera, this is not real micronized progesterone, but rather a synthetic progestin. I've heard bad things about provera in that it causes depression in some patients, although I have never tried it. Injectable would be worse if you are one of the unlucky ones to be susceptible to depression whilst on it, since it would stay in your system for much longer than orals would.
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BunnyBee

I should add this... especially with there being a correlation between taking it and depression symptoms presenting (maybe I'm assuming that?) Depo does sound suspicious.  I would also suggest tweaking hormone levels.  The other things I said may help with coping in the meantime though.

Estrogen did not cause depression for me, for the record.  It affected my mood in a very positive way almost immediately.  I have never taken progesterone.

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JungianZoe

Sarah, Andream... for what you've shared, for those kind words, I wish I had more than a "thank you" to offer.  That really, really touched my heart and gave me all sorts of happy.  :icon_hug:

I know this is a message board, a place to reach out, a safe environment (well... as safe as a message board can be!) to share our thoughts with others, but I never lose touch with the fact that real people are at the heart of every message, and I'm as hesitant to vent or complain here as I am in my everyday life.  It took me two hours last night to build up the courage to write the OP in this thread.  Then I got all nervous that everyone would tell me I was too whiny and self-centered (I had a few other expository posts yesterday that I wanted to take back, but didn't).  It's the treatment I'm used to when I open my mouth.

My friends have been very understanding lately of my need to get stuff off my chest, I only fear that I go too far and do it too often.  They insist I don't, but that internal dictator tells me it's time to stop.  There's nobody in the world that can take an endless barrage of crap from anyone.

Which takes me back to the therapist, and motivation to find a job so I can make visits a bit more frequently.  :laugh:

What was said about suicide always remaining an option once you think about it (much less attempt it, much less attempt it over 20 times in varying degrees of severity) hits far too close to home.  I notice the pattern in my brain: something goes wrong (or I perceive it to go wrong), I catastrophize to the Nth degree, and within five minutes I'm crying and thinking of ways to off myself.  I've lived with this long enough to have counterbalance to those thoughts, and now that I'm full time, I would never in a million years act on them.  I'm beginning to learn to love myself, as well as being patient and compassionate with myself, for the first time in my life.  I finally claimed my true identity and that's not something I could ever give up for a temporary problem that will look better in the morning.

That doesn't make the thoughts or emotions any easier to live with though.  But no worries, Sarah, you won't read about my suicide anywhere.  And that's a promise.  ^-^  I've made that promise to a bunch of people lately.

Quote from: andream on May 02, 2011, 07:46:36 PM
You'd better check! If it's depo provera, this is not real micronized progesterone, but rather a synthetic progestin. I've heard bad things about provera in that it causes depression in some patients, although I have never tried it. Injectable would be worse if you are one of the unlucky ones to be susceptible to depression whilst on it, since it would stay in your system for much longer than orals would.

Yes, what I take is depo provera, yes it's injected, and it lasts three months.  All in line with what you said.  I got my last shot five weeks ago, so I've got another two months to sit this out and hope the situation improves.  I'll bring this up (loudly, if necessary) with my doctor when I have my June visit.  Problem is, spiro didn't work to suppress my T levels, and the depo does.  Don't know what other tricks she'd have up her sleeve if I can't do spiro for physical reasons or depo for emotional ones.
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Joelene9

  I'm on Provera, not Depo with the separate estrodiol.  My Provera dosages are modulated in the first part of the calendar regimen.  I had depression before the HRT but I noticed it gone during the Provera part of the second month on HRT when the dosages were increased!  It was that quick, but gradual enough to be caught off guard.  But why I actually gained muscle mass during this time is a mystery, but welcomed!
  Joelene
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justmeinoz

I suffered from Depression for years, and despite years of therapy and antidepressants,it only  began to lift once I worked out it was largely due to GID.

  I believe it finally ceased about a month before I started HRT ,nearly a month ago, and although there have been a couple of incidents which upset me it hasn't returned.  I now feel a lot more settled and less sensitive to setbacks. 

My Endo basically prescribes the contraceptive pill which contains both Estrogen and micronised Progesteron ( to help shut down the Pituitary and so switch off T production apparently). 

Since I have been taking it I have had a constant slightly euphoric feeling, in a way that I had only begun to  feel intermittently in the weeks prior to HRT. I think it is actually called happiness, but since it is many years since I experienced it for prolonged  periods I am not sure.  I hope so.

Karen.
"Don't ask me, it was on fire when I lay down on it"
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