I'm directly of Native American blood and North American Indians are notorious for having bad luck and being complete drunkards; my entire line of ancestors grew up on plantations in complete poverty.
It's really, in my opinion, all about very fine tuned evolutional mindsets. With Native Americans for example, most Native tribes welcomed and required "Trans" identity clan members; it was a unique identity in Native times and often, these individuals became story tellers, child caregivers, and healers.
Over time, a certain population (especially a very close-knit, small population) can become almost genetically dependent on certain chemical structures and activities that stimulate the brain; with Native Americans, this required mentality happened to be "living off the land, living in free-minded tribes, and generally living by no rules other than respect for the fellow human and animal". This is pretty much what literally fueled the entire race of Natives; this particular lifestyle is what caused their brains to be receptive toward certain reward chemicals.
So naturally, with my own brain, my brain is actually hardwired to be prone to the chemical receptors that activate when I partake in activities that represent freedom, identity, exploration, success, love, and art. Some people just aren't designed to be as receptive to those activities. And quite naturally, from the age of 4, I always knew that I was a writer, a caregiver, a story teller, someone with a sense of adventure, and most of all, I knew that I was trans, and even at the age of 4, I was naturally proud of it more than any discriminatory person could convince me that it was wrong. It just felt natural to me.
For instance, Caucasian people are proven by fMRI's to be more receptive to religious ideals, the supernatural, if you will. Same goes for Blacks. This information starts to divide among Natives and Asians, two races who for thousands of years have never been religious and, at most, used supernatural thoughts as something of entertainment. This is why I feel Native Americans tend to have bad luck in the real world; you have an entire race of people who give less farts about modern Christianity or it's many ideals, and truly, anyone who's naturally Atheist is going to have a heck of a tough time growing up in America.