running away usually doesn't solve any problems, and you risk getting even more miserable unless you're in a life threatening situation or being severely abused. the better choice would be to move out of your parents' house as soon as you can afford your own place, and then take your family's reactions as they come. let them be the ones who severe your family ties if that happens
don't quit college no matter what, it's what will get you a good enough job to afford transition and independence from your family. suffering for a few years while doing what's necessary to become happy is better than suffering for many years because of one bad choice made in a moment of desperation. if it gets too suffocating to stay with your family, go to a friend's place for a few days. i'm enduring life with hopeless parents, but it'll soon pay off. i'm about to get a good job, and in a few months i'll have the freedom i've always wanted