I find that too, especially if I forget to take it. Although, now that I've been on it a while I've got enough in my system that it doesn't happen right away -- but early on, if I forgot I'd go nuts and not be fun to be around. LOL I actually feel a lot more balanced with the estrogen then I did before... the docs said I was bipolar then to explain the mood swings and so on, but now with the estrogen I don't get like that any more. That was one of the things I first noticed, how balanced I felt.