Reply to Ellesmira... Spiro is not meant to be used as testosterone blocker, but mostly antihypertensive and diuretic. Having anti-androgen properties is just one of its side effects, among many other (like drought, I really hated that and everything related). If spironolactone works well for you, and your blood tests show it is sufficient at doing its job, and you can handle all the nasty side effects, than it just might be a perfect testosterone blocker for you. I for example feel a looooooot better since I switched from spiro to cyproterone acetate (Androcur). And there are more other, more effective options, which are primarily anti-androgens, some like Androcur a little more expensive, and some other much more expensive. By far the best thing about spiro is it's dirt cheap and available everywhere. In regards to changes, many people who used spiro reported about more changes and development happening after orchiectomy or SRS.. Taking normal dose of Androcur (or any other powerful TBlocker) basically does the same as orchie or SRS in relation to testosterone factory. Taking dutasteride along it also doesn't do any bad, rather only good at least as hair goes.