I first came out to one of my friends. I had just recently come out of denial, and needed to talk as I was falling apart at the time. I picked her because of all my friends, she was the most vocal advocate of lgbt rights, so I figured the chances of her disowning me would be smaller (and if she did, I could at least call her a hypocrite). Moreover, most of my other friends know each other, while she's off in her own little circle, so if things went poorly, at least the fallout would be minimized. Fortunately, none of that came to pass, and she's been extremely supportive. In fact, I get the impression she's looking forward to teaching me all sorts of girl things: being the big sister if you will.
The second person I came out to was my mother. She's accepting. I get the impression she doesn't always understand what's going on, but she means well at least.