It may not matter to you but it may matter to other people. It may not be at work. It may be at school, in family, or where ever. Not everybody will pick up on everything, but people will notice, and they will talk, or wonder.
Lip gloss isn't as subtle as we think it is. Nails really bother some people. A lot of times women will react to the brows.
It's important for people to realize that it does get noticed, and either be confident about it, or have a good answer. Either way, don't get flustered when someone calls you on it.