It really all depends on the type of Medes and how your body handles them. I am 36, started <not allowed>Delestrogen bi-weekly injections and <not allowed> Spironolactone daily on April 22, 2016 and have had some amazing results. Within 1st week, nipples and surrounding tissue was very sore with small nodules forming behind them, since have spread and become pretty noticeable without a sports bra. I would say more than half an Acup! By the end of the 1month, my skin was dryer and sooooo smooooth! The majority of my muscles have lost the firmness that they once had, and are getting a little smaller, most notably in my arms. My hips started aching at about month 2 but that is normal as well. The ligaments in the hips will loosen a bit and they rotate forward. Went in for blood work on June 10th and my T is suppressed with my E being a little on the high side, so injections were scaled back to <not allowed>. Oh and to help with the breast tenderness try a heating pad, works wonders!! I hope this info helps!
Moderator edit: Dosages are not allowed.