Welcome to Susan's Place. Normally you don't get a choice however Etradiol, 17-beta or Estradiol valerate are equally effective. You should avoid Conjugated estrogens as they are quite expensive and aren't really the best option when one of the other two is available. I was on Conjugated estrogens for years as at one time it was the best thing that was available however I am now on Etradiol, 17-beta. Etradiol, 17-beta is cheap, effective and safe so I prefer it to my previous treatment. Estradiol valerate is probably more expensive but it converts to Etradiol, 17-beta in the body so there shouldn't be much difference between the two.