I have always been in European male 41-42 range, closer to 41. I noticed that when I picked one pair of shoes, which were quite comfortable for me, put them on and then literally stepped out of them... So now, I am 40-41, which get quite complicated, because 41 is essentially the lowest size one can get here. It happened pretty fast and in my opinion was mostly related to weight loss. The HRT has affected my soles though - they are softer and smoother now, which is nice for touching but has resulted in several tripping accidents when I walked bare-feet on slippery floor tiles... Never really bothered about that before and then whooops and my back hits the floor and I feel stupid...